Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Metabolism: Phase II Reactions01:14

Drug Metabolism: Phase II Reactions

4.5K
Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
4.5K
Drug Metabolism: Phase I Reactions01:17

Drug Metabolism: Phase I Reactions

4.1K
A phase I reaction is a biochemical process that introduces a functionally reactive polar group to a substance. This transformation predominantly occurs in the liver, facilitated by the cytochrome P450 system of hemoproteins situated in the lipophilic endoplasmic reticulum of cells. The metabolite generated through this process can have varying polarities. If it is sufficiently polar, it can be easily excreted in the urine due to its water compatibility. However, if the metabolite is nonpolar,...
4.1K
Introduction to Metabolism01:30

Introduction to Metabolism

1.3K
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
1.3K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

3.2K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
3.2K
Drug Biotransformation: Overview01:28

Drug Biotransformation: Overview

1.9K
Biotransformation, also known as drug metabolism, is a vital physiological process that chemically alters drugs, facilitating their elimination from the body and terminating their action. This process involves two main phases: phase I and phase II reactions. Phase I reactions, including oxidation, reduction, and hydrolysis, introduce or unmask polar functional groups on the drug molecule, thereby increasing its water solubility. By enhancing water solubility, the drug becomes more hydrophilic...
1.9K
What is Metabolism?00:52

What is Metabolism?

123.3K
Overview
123.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid adaptation and extinction in synchronized outdoor evolution experiments of <i>Arabidopsis</i>.

Science (New York, N.Y.)·2026
Same author

Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in <i>Arabidopsis</i>.

eLife·2025
Same author

Population-aware permutation-based significance thresholds for genome-wide association studies.

Bioinformatics advances·2024
Same author

The benefits of permutation-based genome-wide association studies.

Journal of experimental botany·2024
Same author

Global Genetic Heterogeneity in Adaptive Traits.

Molecular biology and evolution·2021
Same author

Genetic mapping of the early responses to salt stress in Arabidopsis thaliana.

The Plant journal : for cell and molecular biology·2021
Same journal

SqueakPose Studio, an end-to-end platform for pose estimation and real-time edge-AI deployment.

eLife·2026
Same journal

Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival.

eLife·2026
Same journal

Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode.

eLife·2026
Same journal

Lipid packing contributes to the confinement of caveolae to the plasma membrane.

eLife·2026
Same journal

A coma pattern-based autofocusing method resolves bacterial cold shock response at single-cell level.

eLife·2026
Same journal

Non-canonical amino acid incorporation enables minimally disruptive labeling of stress granule and TDP-43 proteinopathy.

eLife·2026
See all related articles

Related Experiment Video

Updated: Nov 2, 2025

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

34.3K

Getting the metabolites right.

Arthur Korte1

  • 1Center for Computational and Theoretical Biology, University of Würzburg, Würzburg, Germany.

Elife
|June 15, 2021
PubMed
Summary
This summary is machine-generated.

Environmental and evolutionary pressures significantly shape plant metabolites, as demonstrated by a European study of nearly 800 Arabidopsis thaliana plants. This research highlights the intricate relationship between external factors and the chemical compounds within plants.

Keywords:
Arabidopsis thalianaconvergence evolutionecologyglucosinolatesparallel evolutionplant biologyspecialized metabolites

More Related Videos

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

21.2K
One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
09:28

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

13.4K

Related Experiment Videos

Last Updated: Nov 2, 2025

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis
11:25

Multi-step Preparation Technique to Recover Multiple Metabolite Compound Classes for In-depth and Informative Metabolomic Analysis

Published on: July 11, 2014

34.3K
A Strategy for Sensitive, Large Scale Quantitative Metabolomics
14:18

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

21.2K
One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
09:28

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure

Published on: June 25, 2010

13.4K

Area of Science:

  • Plant Science
  • Metabolomics
  • Evolutionary Biology

Background:

  • Plant metabolism is influenced by environmental conditions and evolutionary history.
  • Understanding these influences is key to predicting plant adaptation and chemical diversity.

Purpose of the Study:

  • To investigate how environmental factors and evolutionary pressures shape the metabolic profiles of Arabidopsis thaliana.
  • To identify specific metabolites affected by geographic location and adaptation.

Main Methods:

  • Analysis of metabolic profiles from nearly 800 Arabidopsis thaliana individuals sampled across Europe.
  • Utilizing comparative metabolomics and population genetics approaches.

Main Results:

  • Significant variation in metabolite composition was observed across different European populations.
  • Specific environmental gradients correlated with distinct metabolic patterns, suggesting adaptive responses.
  • Evolutionary history also played a role in shaping the overall metabolic landscape.

Conclusions:

  • Environmental heterogeneity and evolutionary trajectories are critical drivers of plant metabolic diversity in Arabidopsis thaliana.
  • The findings provide insights into the adaptive potential of plants in response to changing environments.