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Updated: Nov 2, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Myocardial strain and left ventricular geometry: a meta-analysis of echocardiographic studies in systemic

Marijana Tadic1, Carla Sala2, Stefano Carugo2

  • 1University Hospital 'Dr Dragisa Misovic - Dedinje' Department of Cardiology, Belgrade, Serbia.

Journal of Hypertension
|June 15, 2021
PubMed

Insights

This meta-analysis shows that left ventricular global longitudinal strain (GLS) is a better indicator of systolic dysfunction in hypertensive heart disease than ejection fraction. GLS deteriorates with increasing left ventricular hypertrophy (LVH) and geometric changes.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Hypertension Research

Background:

  • Hypertensive heart disease is characterized by abnormal left ventricular (LV) geometry.
  • Evidence linking LV mechanics and systolic dysfunction in these patients is limited.

Purpose of the Study:

  • To systematically analyze 2D/3D speckle-tracking studies.
  • To provide comprehensive information on LV mechanics in hypertensive heart disease with abnormal LV geometry.

Main Methods:

  • Systematic meta-analysis of studies published up to January 2021.
  • Searched PubMed, OVID-MEDLINE, and Cochrane Library using terms like 'myocardial strain', 'speckle tracking echocardiography', and 'hypertensive heart disease'.
  • Included data from 267 controls and 712 hypertensive patients across eight studies.

Main Results:

  • Ejection fraction was similar between normotensive and hypertensive groups.
  • LVMI and E/e' increased with worsening LV geometry (normal, concentric remodeling, eccentric LVH, concentric LVH).
  • LV global longitudinal strain (GLS) was significantly lower in all hypertensive groups, particularly in eccentric and concentric LVH, and showed a progressive decline with increasing LVH severity.

Conclusions:

  • GLS is superior to ejection fraction in detecting systolic dysfunction in hypertensive patients.
  • GLS decline is associated with structural and geometric alterations in the LV, such as LVH.
Abstract

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