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Updated: Nov 2, 2025

The C. elegans Excretory Canal as a Model for Intracellular Lumen Morphogenesis and In Vivo Polarized Membrane Biogenesis in a Single Cell: labeling by GFP-fusions, RNAi Interaction Screen and Imaging
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Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs

Arun A Chandrakumar1,2, Étienne Coyaud2, Christopher B Marshall2

  • 1Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

The Journal of Cell Biology
|June 15, 2021
PubMed
Summary

Tankyrase suppresses SH3BP5 and SH3BP5L, inhibiting Rab11a activation and cyst lumen formation. RNF146 reverses this, restoring epithelial polarity and lumen development.

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