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Polymer-Based Honeycomb Films on Bioactive Glass: Toward a Biphasic Material for Bone Tissue Engineering

A Deraine1,2, M T Rebelo Calejo2, R Agniel1

  • 1ERRMECe, Equipe de Recherche sur les Relations Matrice Extracellulaire-Cellules (EA1391), Université de Cergy-Pontoise, Maison Internationale de la Recherche (MIR), Rue Descartes, 95001 Neuville sur Oise, Cedex, France.

ACS Applied Materials & Interfaces
|June 15, 2021
PubMed
Summary

This study developed a stable biphasic material for bone regeneration by combining bioactive glasses with poly-l-co-d,l-lactic acid honeycomb membranes. Surface modifications enhanced membrane stability, crucial for preventing fibrous tissue infiltration during bone healing.

Keywords:
bioactive glassbiphasic materialbone tissue engineeringhoneycomb membranein vitro stability

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Materials Chemistry

Background:

  • Innovative materials are crucial for bone regeneration, needing to promote healing while preventing fibrous tissue infiltration.
  • Bioactive glasses (BaGs) offer osteopromotive properties, while poly-l-co-d,l-lactic acid (PLDLA) provides biodegradability and ease of handling.

Purpose of the Study:

  • To investigate the impact of bioactive glass surface chemistry and topography on the stability of a PLDLA honeycomb membrane.
  • To assess the membrane's performance in both dry and wet conditions for potential bone tissue engineering applications.

Main Methods:

  • PLDLA honeycomb membranes were fabricated on various bioactive glass substrates using the breath figure method (BFM).
  • Substrates included untreated BaG discs (S53P4, 13-93B20), silanized discs (APTES), and conditioned discs (TRIS buffer immersion).
  • Membrane stability was evaluated by resistance to shear and immersion in TRIS buffer.

Main Results:

  • All deposited PLDLA membranes exhibited a consistent honeycomb structure with 1-5 μm pores.
  • Surface treatments, specifically APTES grafting (amine groups) and conditioning (CaP layer), significantly enhanced membrane stability.
  • Modified surfaces improved resistance to shear and stability in aqueous environments.

Conclusions:

  • Controlling substrate surface chemistry is key to fabricating stable polymer membranes on bioactive glasses.
  • This biphasic material approach is a promising step towards developing osteostimulative materials that also physically block fibrous tissue infiltration.