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Overactive bladder phenotypes: development and preliminary data.

Jerry G Blaivas1, Eric S W Li, Linda Dayan

  • 1Icahn School of Medicine at Mount Sinai, New York, New York, USA.

The Canadian Journal of Urology
|June 15, 2021
PubMed
Summary
This summary is machine-generated.

This study developed overactive bladder (OAB) phenotypes using voided volume, maximum voided volume, and post-void residual urine. These classifications aid in understanding OAB causes and creating targeted diagnostic and treatment strategies.

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Area of Science:

  • Urology
  • Nephrology
  • Clinical Medicine

Background:

  • Overactive bladder (OAB) presents a significant clinical challenge with varied underlying etiologies.
  • Developing distinct patient phenotypes is crucial for personalized medicine approaches in OAB management.

Purpose of the Study:

  • To establish overactive bladder (OAB) phenotypes for improved diagnostic and treatment pathways.
  • To identify potential etiological clues for OAB patients through phenotypic classification.

Main Methods:

  • Retrospective, multicenter study involving patients with lower urinary tract symptoms (LUTS).
  • Utilized 24-hour bladder diary (24HBD), lower urinary tract symptoms score (LUTSS), uroflowmetry (Q), and post-void residual urine (PVR) measurements.
  • Developed a phenotype classification system based on 24-hour voided volume (24HV), maximum voided volume (MVV), Qmax, and PVR.

Main Results:

  • Three primary phenotypes were identified based on 24HV: polyuria (>2.5 L, 25%), normal (1-2.5 L, 63%), and oliguria (<1 L, 11%).
  • These were further subdivided into 18 subtypes based on MVV, Qmax, and PVR.
  • OAB was present in 75% of the 533 study participants.

Conclusions:

  • Phenotypic classification of OAB variants offers a foundation for further research.
  • This approach supports the development of granular diagnostic and treatment algorithms for OAB.
  • Understanding OAB phenotypes can advance research into etiology and treatment outcomes.