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Research Relevant Conditions and Pathology in Nonhuman Primates
Chandra Saravanan1, Thierry Flandre2, Carolyn L Hodo3
1Novartis, Novartis Institutes for BioMedical Research, Preclinical Safety, Cambridge, Massachusetts 02139, USA.
ILAR Journal
|June 15, 2021
Summary
Understanding background histopathologic changes in nonhuman primates (NHPs) is crucial for accurate biomedical research. This review details common findings in various NHP species to improve study validity.
Area of Science:
- Veterinary Pathology
- Translational Research
- Comparative Medicine
Background:
- Nonhuman primates (NHPs) are vital models in biomedical research due to their similarity to humans.
- Histopathologic changes in tissues are key endpoints in NHP studies.
- Spontaneous or background lesions can complicate the interpretation of experimental findings.
Purpose of the Study:
- To provide a comprehensive summary of research-relevant conditions and pathology in commonly used NHP species.
- To aid researchers in distinguishing background findings from study-related changes.
- To enhance the validity and interpretation of NHP research.
Main Methods:
- Review of existing literature on NHP pathology.
- Compilation of histopathologic findings across multiple NHP species.
- Analysis of factors influencing background lesions (species, age, origin, xenobiotics).
Main Results:
- Detailed descriptions of expected histopathologic changes in various NHP species.
- Identification of common confounding factors in NHP research.
- Emphasis on the impact of experimental conditions on background pathology.
Conclusions:
- Accurate identification of background pathology is essential for valid NHP research.
- This review serves as a resource for researchers working with NHPs.
- Improved understanding of NHP pathology enhances translational research outcomes.
