Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical geometry in sequence space: a method of quantitative comparative sequence analysis.

M Eigen1, R Winkler-Oswatitsch, A Dress

  • 1Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Federal Republic of Germany.

Proceedings of the National Academy of Sciences of the United States of America
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-beam cross-correlation:  a method to characterize transport phenomena in micrometer-sized structures.

Analytical chemistry·2011
Same author

Selforganization in molecular and cellular networks.

Neurochemistry international·2010
Same author

What is a quasispecies?

Current topics in microbiology and immunology·2006
Same author

Delta plots: a tool for analyzing phylogenetic distance data.

Molecular biology and evolution·2002
Same author

Theodor Hermann Felix Wieland (5 June 1913-24 November 1995).

Proceedings of the American Philosophical Society·2001
Same author

Mysticism and psychoanalysis.

Psychoanalytic review·2001
Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

This study introduces a novel statistical method for sequence analysis, enhancing the accuracy of phylogenetic tree reconstruction and noise level determination in comparative genomics. The method demonstrates high sensitivity in identifying evolutionary relationships, even with noisy data.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Statistical Genetics

Background:

  • Comparative sequence analysis is crucial for understanding evolutionary relationships.
  • Existing methods may struggle with noisy data or complex evolutionary histories.
  • Accurate determination of evolutionary topology and noise levels remains a challenge.

Purpose of the Study:

  • To introduce a new statistical method for comparative sequence analysis.
  • To enhance the accuracy of phylogenetic topology calibration.
  • To enable quantitative noise level determination in sequence data.

Main Methods:

  • The method combines horizontal and vertical correlations in aligned sequences.
  • It analyzes quartet combinations of sequences as geometric configurations in sequence space.

Related Experiment Videos

  • Numerical invariants and statistical averages are used for analysis and calibration.

    • Main Results:

    • The method achieves high sensitivity in assigning basic topologies, even with randomized data.
    • It allows for quantitative determination of the noise level.
    • Vertical analysis enables the study of divergences with positionally varying substitution probabilities.

    Conclusions:

    • The introduced statistical method offers a robust approach to comparative sequence analysis.
    • It improves the reliability of phylogenetic inference and evolutionary studies.
    • The method is sensitive to subtle topological differences and adaptable to varying substitution rates.