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Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Related Experiment Video

Updated: Nov 2, 2025

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
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Liver Fibrosis Assessment.

Mayur Virarkar1, Ajaykumar C Morani2, Melissa W Taggart3

  • 1Department of Neuroradiology, The University of Texas Health Science Center, Houston, TX.

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Summary

Early diagnosis of hepatic fibrosis (HF) is crucial for preventing cirrhosis. This review explores non-invasive imaging techniques like CT, MRI, and US for accurate HF diagnosis and management.

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Area of Science:

  • Radiology
  • Hepatology
  • Medical Imaging

Background:

  • Hepatic fibrosis (HF) is a key indicator of chronic liver disease, potentially progressing to cirrhosis and cancer.
  • Liver biopsy, the traditional diagnostic method, is invasive and prone to sampling errors.
  • Conventional imaging (US, CT, MRI) assesses cirrhosis morphology, but newer methods offer greater accuracy.

Purpose of the Study:

  • To review non-invasive imaging modalities for hepatic fibrosis (HF) diagnosis and stratification.
  • To highlight the importance of early HF detection for disease management.
  • To discuss the role of advanced imaging techniques in liver disease assessment.

Main Methods:

  • Review of current literature on non-invasive imaging for hepatic fibrosis.
  • Discussion of conventional imaging techniques (ultrasound, CT, MRI).
  • Exploration of advanced modalities including MRI elastography, US elastography, diffusion-weighted MRI, and perfusion CT.

Main Results:

  • Non-invasive imaging modalities show promise for accurate hepatic fibrosis diagnosis.
  • Newer techniques like MRI and US elastography offer reliable and accurate assessments.
  • Advanced MRI and CT techniques require further research for optimal clinical application.

Conclusions:

  • Non-invasive imaging, particularly advanced techniques, is essential for early hepatic fibrosis diagnosis and management.
  • These methods can help prevent progression to cirrhosis and hepatocellular carcinoma.
  • Further research into novel imaging modalities will enhance surveillance and treatment strategies.