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Mortality in Patients With Genetic and Environmental Risk of Liver Disease
Carolin V Schneider1,2, Malin Fromme2, Kai Markus Schneider2,3
1The Institute for Translational Medicine and Therapeutics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Introduction:
The increasing liver-related mortality calls for hepatic surveillance programs. To design them, factors selectively increasing liver-related vs overall mortality need to be identified.
Methods:
We analyzed mortality data from 467,558 individuals recruited by the community-based UK Biobank. The mean follow-up was 11.4 years.
Results:
While all assessed genetic factors associated with increased liver-specific mortality, only homozygous TM6SF2 mutation and SERPINA1 mutation conferred elevated overall mortality. Among the environmental factors, obesity and metabolic syndrome disproportionately contributed to liver-related deaths.
Discussion:
Our data demonstrate an interplay between genetics and environment and provide a basis for hepatic surveillance programs.
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