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SPR perspectives: Environmental influences on Child Health Outcomes (ECHO) Program: overcoming challenges to generate
Kaja Z LeWinn1, Elizabeth Caretta2, Ann Davis3
1Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Insights
The Environmental influences on Child Health Outcomes (ECHO) Program unites over 57,000 children to study early life environmental factors impacting pediatric health. This large-scale initiative aims to improve children's health outcomes for future generations.
Area of Science:
- Pediatric Health Research
- Environmental Health
- Public Health
Background:
- Many US children face chronic health issues or developmental challenges.
- Early life environmental exposures are critical to child health.
- The Environmental influences on Child Health Outcomes (ECHO) Program addresses key pediatric outcome areas.
Purpose of the Study:
- To describe the ECHO Program's infrastructure for large-scale collaboration.
- To outline challenges overcome in launching the program.
- To foster solution-oriented research for improving children's health.
Main Methods:
- Established a national network of 69 existing cohort studies.
- Engaged over 1200 investigators in a collaborative team science approach.
- Developed a unified, cohort-wide data collection protocol.
Main Results:
- Successfully launched a large-scale, multi-cohort program.
- Facilitated collaboration across diverse research disciplines.
- Initiated research focused on modifiable environmental influences on child health.
Conclusions:
- The ECHO Program provides a robust infrastructure for impactful pediatric research.
- Team science and stakeholder engagement are key to addressing complex child health issues.
- The program is positioned to generate high-impact findings to improve children's health for generations.
Abstract:
The US National Institutes of Health-funded Environmental influences on Child Health Outcomes (ECHO) Program brings together 69 cohorts and over 57,000 children from across the nation to address five key pediatric outcome areas with high public health impact: pre-, peri-, and postnatal outcomes; upper and lower airway health; obesity; neurodevelopment; and positive health. We describe (1) the ECHO Program infrastructure that was designed to facilitate collaboration across over 1200 investigators and support the development of a cohort-wide data collection protocol and (2) the many challenges that were overcome in rapidly launching this large-scale program. Guided by a commitment to transparency, team science, and end user stakeholder engagement, ECHO successfully launched a unified study protocol and is working across disciplines to generate high-impact, solution-oriented research to improve children's lives for generations to come. IMPACT: Many children in the United States experience chronic health conditions or do not reach their developmental potential. The Environmental influences on Child Health Outcomes (ECHO) Program brings together 69 existing cohort studies comprising over 57,000 children to identify modifiable aspects of the early environment associated with pediatric outcomes with high public health impact: pre-, peri-, and postnatal outcomes; upper and lower airway health; obesity; neurodevelopment; and positive health. We describe the collaborative, team science-informed approach by which over 1200 investigators convened to form the ECHO Program and foster solution-oriented research to improve the health of children for generations to come.
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