Related Experiment Video
Updated: Nov 2, 2025

Isolation and Transcriptome Analysis of Plant Cell Types
Published on: April 7, 2023
Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots
Isabel Betegón-Putze1, Josep Mercadal2,3, Nadja Bosch1
1Department of Molecular Genetics, Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus UAB (Cerdanyola del Vallès), Barcelona, Spain.
Abstract:
Understanding stem cell regulatory circuits is the next challenge in plant biology, as these cells are essential for tissue growth and organ regeneration in response to stress. In the Arabidopsis primary root apex, stem cell-specific transcription factors BRAVO and WOX5 co-localize in the quiescent centre (QC) cells, where they commonly repress cell division so that these cells can act as a reservoir to replenish surrounding stem cells, yet their molecular connection remains unknown. Genetic and biochemical analysis indicates that BRAVO and WOX5 form a transcription factor complex that modulates gene expression in the QC cells to preserve overall root growth and architecture. Furthermore, by using mathematical modelling we establish that BRAVO uses the WOX5/BRAVO complex to promote WOX5 activity in the stem cells. Our results unveil the importance of transcriptional regulatory circuits in plant stem cell development.
Related Concept Videos
Gene Regulation During Sporulation
Transcription Attenuation in Prokaryotes
There are several different mechanisms used to attenuate transcription. In ribosome mediated...
Master Transcription Regulators
Master Transcription Regulators
Regulation of Expression at Multiple Steps
Cell Signaling in Plants

