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Ynamides as Three-Atom Components in Cycloadditions: An Unexplored Chemical Reaction Space

Dominic Campeau1, Alice Pommainville1, Fabien Gagosz1

  • 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, K1N 6N5, Ottawa, Canada.

Journal of the American Chemical Society
|June 16, 2021
PubMed
Summary

Ynamides act as neutral three-atom components (TACs) in (3+2) cycloadditions with alkynes. This reaction efficiently synthesizes functionalized pyrroles via a novel pathway, expanding heterocyclic chemistry.

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