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Related Experiment Video

Updated: Nov 2, 2025

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

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Published on: May 17, 2024

Atypical Fibroxanthoma Demonstrating HMB45+ Staining.

Vikram N Sahni¹, Dev R Sahni², David S Cassarino³

¹College of Medicine, Drexel University, Philadelphia, PA.

The American Journal of Dermatopathology

|June 16, 2021

Summary

Atypical fibroxanthoma (AFX) diagnosis can be challenging. This case highlights a rare HMB45-positive AFX, emphasizing caution when using single immunohistochemical markers for diagnosis.

Area of Science:

Dermatopathology
Oncology
Histopathology

Background:

Atypical fibroxanthoma (AFX) is a superficial fibrohistiocytic tumor.

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AFX is typically diagnosed by exclusion, ruling out melanoma and sarcomas.

Commonly, AFX expresses CD68 and smooth muscle actin, and is negative for melanocytic markers like HMB45 and S100.