Site-selective D2O-mediated deuteration of diaryl alcohols via quantum dots photocatalysis
Xiao-Lei Nan1, Yao Wang1, Xu-Bing Li1
1Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing 100190, People's Republic of China. lixubing@mail.ipc.ac.cn lzwu@mail.ipc.ac.cn and School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Abstract:
Owing to the high synthetic value of deuteration in the pharmaceutical industry, we describe herein the conversion of a range of aromatic ketones to deuterium-labeled products in good to excellent yields. Efficient and site-selective deuteration of benzyl alcohols by D2O with visible light irradiation of quantum dots (QDs), together with gram-scale synthesis and photocatalyst recycling experiments indicated the potential of the developed method in practical organic synthesis.
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