Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

12.4K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
12.4K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.6K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.6K
Immunological Memory01:23

Immunological Memory

12.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
12.7K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

77.8K
Overview
77.8K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

13.5K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
13.5K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

6.9K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Granzyme A-expressing Terminal Effector T Cells Dedifferentiate into Long-lived Memory T Cells.

Research square·2026
Same author

Sustained A2AR expression and loss paradoxically promote CD8<sup>+</sup> T cell exhaustion.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

PIM1 kinase-regulated cellular metabolism sustains differentiation and function of effector CD8+ T cells during chronic viral infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

ZFP148 is a transcriptional repressor of cytolytic effector CD8<sup>+</sup> T cell differentiation.

Nature immunology·2026
Same author

KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Stepwise differentiation from precursor intermediates and distinct Th1 checkpoints promote CD4 Th1 cell differentiation during chronic viral infection.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Nov 2, 2025

Generation of Induced Regulatory T Cells from Primary Human Na&#239;ve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.4K

Inhibiting BRD4 to generate BETter T cell memory.

Moujtaba Y Kasmani, Weiguo Cui

    The Journal of Experimental Medicine
    |June 16, 2021
    PubMed
    Summary

    Bromodomain-containing protein 4 (BRD4) is crucial for CD8 T cell effector functions during infection and cancer. This protein regulates transcription by binding to acetylated histones, impacting immune responses.

    Area of Science:

    • Immunology
    • Molecular Biology
    • Epigenetics

    Background:

    • Bromodomain-containing protein 4 (BRD4) is a key epigenetic regulator involved in transcriptional control.
    • CD8 T cells are critical immune cells for clearing infections and eliminating cancer cells.
    • The precise role of BRD4 in CD8 T cell effector functions remains incompletely understood.

    Purpose of the Study:

    • To investigate the role of BRD4 in the effector functions of CD8 T cells.
    • To elucidate the molecular mechanisms by which BRD4 influences T cell responses to infection and cancer.

    Main Methods:

    • Utilized mouse models of infection and cancer.
    • Employed genetic and pharmacological inhibition of BRD4 in CD8 T cells.
    • Assessed T cell proliferation, cytokine production, and cytotoxic activity.

    More Related Videos

    Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
    07:25

    Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

    Published on: September 25, 2019

    7.0K
    Murine Superficial Lymph Node Surgery
    04:36

    Murine Superficial Lymph Node Surgery

    Published on: May 21, 2012

    43.0K

    Related Experiment Videos

    Last Updated: Nov 2, 2025

    Generation of Induced Regulatory T Cells from Primary Human Na&#239;ve and Memory T Cells
    14:23

    Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

    Published on: April 16, 2012

    24.4K
    Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
    07:25

    Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

    Published on: September 25, 2019

    7.0K
    Murine Superficial Lymph Node Surgery
    04:36

    Murine Superficial Lymph Node Surgery

    Published on: May 21, 2012

    43.0K

    Main Results:

    • BRD4 is essential for the optimal effector function of CD8 T cells.
    • BRD4 deficiency impairs T cell proliferation, cytokine secretion, and tumor control.
    • BRD4 regulates genes critical for T cell activation and function.

    Conclusions:

    • BRD4 is a critical regulator of CD8 T cell effector functions in response to infection and cancer.
    • Targeting BRD4 may represent a therapeutic strategy to enhance anti-infective and anti-cancer immunity.