Related Experiment Video

Updated: Nov 2, 2025

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

120

COVID-19-related Gastrointestinal Bleeding in a Pediatric Patient With ALL

Małgorzata Wojciechowska1, Joanna Renke, Ninela Irga-Jaworska

  • 1Department of Pediatric Hematology and Oncology, Medical University of Gdańsk, Gdańsk, Poland.

Journal of Pediatric Hematology/Oncology
|June 16, 2021
PubMed

Insights

This case study highlights an 11-year-old boy with B-cell acute lymphoblastic leukemia experiencing an unusual COVID-19 course. The severe acute respiratory syndrome coronavirus-2 infection presented with gastrointestinal bleeding before respiratory symptoms.

Area of Science:

  • Pediatric Oncology
  • Infectious Diseases
  • Hematology

Background:

  • Patients with hematologic malignancies face increased mortality risk from COVID-19.
  • Data on COVID-19 in pediatric acute lymphoblastic leukemia (ALL) patients are limited.
  • This study focuses on a pediatric B-cell ALL case with an atypical COVID-19 presentation.

Observation:

  • An 11-year-old male undergoing chemotherapy for B-cell ALL tested positive for SARS-CoV-2.
  • Chemotherapy was continued due to the absence of initial COVID-19 symptoms.
  • The patient developed severe gastrointestinal bleeding followed by respiratory tract infection.

Findings:

  • The pediatric ALL patient exhibited an atypical COVID-19 progression.
  • Gastrointestinal bleeding preceded the severe respiratory illness.
  • The case underscores the varied clinical manifestations of COVID-19 in immunocompromised children.

Implications:

  • Highlights the need for vigilance regarding non-respiratory symptoms of COVID-19 in pediatric leukemia patients.
  • Suggests potential for severe gastrointestinal complications in this vulnerable population.
  • Contributes to understanding the spectrum of severe acute respiratory syndrome coronavirus-2 in immunocompromised children.

More Related Videos

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia09:57

Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia

Published on: March 5, 2018

29.9K
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.3K

Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
201
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
49
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
600
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
465
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
55