Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

3.3K
Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
3.3K
Stability of Conjugated Dienes01:28

Stability of Conjugated Dienes

3.8K
Introduction
A comparison of the enthalpies of hydrogenation of dienes reveals that conjugated dienes release less heat on hydrogenation, rendering them more stable than their nonconjugated analogs.
3.8K
Plant Hormones01:56

Plant Hormones

25.7K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
25.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chiral π-conjugated polymer films <i>via</i> kinetically controlled dip-coating for circularly polarized light information encoding.

Nanoscale·2026
Same author

Patient‑specific profiling of TCR‑T cell efficacy enabled by a rapid and standardized reporter system.

Protein & cell·2026
Same author

A Comparative Study on the Identification of Xanthium sibiricum Patrin ex Widder and Xanthium italicum Moretti Based on Three Microscopy Technology.

Microscopy research and technique·2026
Same author

Optimized extraction, isolation and identification of bioactive sesquiterpenes from Inula racemosa.

Bioorganic chemistry·2025
Same author

Investigating the interaction mechanism of five flavonoids and PD-L1 based on multi-spectroscopy and molecular dynamics.

Chemico-biological interactions·2025
Same author

Molecular networking-based discovery of components with antioxidant and α-glucosidase inhibitory activities in burdock root.

Food chemistry·2025

Related Experiment Video

Updated: Nov 2, 2025

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
08:56

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

17.7K

Bioactive sesquiterpenes from Inula helenium.

Xiaoqin Zheng1, Zi Wu1, Jie Xu1

  • 1Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.

Bioorganic Chemistry
|June 16, 2021
PubMed
Summary
This summary is machine-generated.

New compounds from Inula helenium roots show potential in cancer therapy and inflammation. Six sesquiterpenes enhance chemotherapy, while fifteen exhibit anti-inflammatory properties, offering new drug development avenues.

Keywords:
Anti-inflammatoryChemosensitizerInula heleniumSesquiterpene

More Related Videos

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

10.1K
A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC
10:09

A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC

Published on: March 15, 2017

25.9K

Related Experiment Videos

Last Updated: Nov 2, 2025

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
08:56

Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

Published on: August 16, 2018

17.7K
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

10.1K
A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC
10:09

A Straightforward Method for Glucosinolate Extraction and Analysis with High-pressure Liquid Chromatography HPLC

Published on: March 15, 2017

25.9K

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Pharmacology

Background:

  • Inula helenium (elecampane) roots are a source of diverse sesquiterpenes.
  • Drug resistance in ovarian cancer and the need for novel anti-inflammatory agents are significant challenges.
  • Understanding structure-activity relationships is crucial for drug development.

Purpose of the Study:

  • To isolate and characterize eudesmane-type sesquiterpenes from Inula helenium roots.
  • To investigate the synergistic effects of these compounds with cisplatin against ovarian cancer cells.
  • To evaluate the anti-inflammatory potential of the isolated sesquiterpenes.

Main Methods:

  • Isolation of 21 eudesmane-type sesquiterpenes, including 5 new compounds.
  • Structure elucidation using spectroscopic data (NMR, MS), single-crystal X-ray diffraction, and ECD calculations.
  • Assessment of synergistic effects with cisplatin on ovarian cancer cells and evaluation of anti-inflammatory activity.

Main Results:

  • Five new eudesmane-type sesquiterpenes were identified and their structures confirmed.
  • Six compounds demonstrated synergistic enhancement of cisplatin's efficacy against ovarian cancer cells.
  • Fifteen sesquiterpenes displayed significant anti-inflammatory activity.

Conclusions:

  • The study identified novel sesquiterpenes from Inula helenium with potential therapeutic applications.
  • The revealed structure-activity relationship for synergistic effects with cisplatin offers insights for overcoming cancer drug resistance.
  • The identified anti-inflammatory sesquiterpenes are promising candidates for developing new anti-inflammatory drugs.