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Inhalable liposomes for treating lung diseases: clinical development and challenges
Pranav Ponkshe1, Sheng Feng1, Chalet Tan1
1Department of Pharmaceutics and Drug Delivery, University of Mississippi School of Pharmacy, University, Mississippi 38655, The United States.
Biomedical Materials (Bristol, England)
|June 16, 2021
Summary
Inhaled liposomal drugs offer significant benefits for treating lung diseases. This review covers the principles and clinical progress of using liposomes for pulmonary drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Pulmonary Medicine
Background:
- Liposomal drug formulations are increasingly utilized for targeted delivery.
- Pulmonary diseases represent a major therapeutic challenge, necessitating innovative treatment strategies.
- Inhalation offers a direct route for drug administration to the lungs.
Purpose of the Study:
- To review the general principles of pulmonary drug delivery using liposomes.
- To discuss the clinical development and applications of inhalable liposomal drugs.
- To highlight the advantages of liposomal inhalation for treating lung conditions.
Main Methods:
- Literature review of preclinical and clinical studies on inhalable liposomes.
- Analysis of general principles governing drug deposition and absorption in the lungs.
- Examination of the regulatory and developmental pathways for inhaled liposomal therapeutics.
Main Results:
- Inhalable liposomes demonstrate potential for enhanced drug efficacy and reduced systemic toxicity.
- Several liposomal drug formulations are currently in clinical trials for various pulmonary indications.
- The review synthesizes key findings on the formulation, characterization, and performance of inhalable liposomes.
Conclusions:
- Inhalation delivery of liposomal drugs presents a promising approach for managing pulmonary diseases.
- Further clinical development is warranted to fully realize the therapeutic potential of this drug delivery system.
- Liposomal inhalation technology offers a versatile platform for treating a spectrum of lung disorders.
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