Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

31.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.8K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.9K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.9K
Aging01:26

Aging

372
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
372
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

56
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
56
Bone Disorders01:29

Bone Disorders

4.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Evaluation of an Integrated Tri-Modal Transdermal Device for Enhanced Serum Absorption.

Journal of cosmetic dermatology·2026
Same author

Blood Microbiota Profile Is Associated with the Responsiveness of Postprandial Lipemia to <i>Platycodi radix</i> Beverage: A Randomized Controlled Trial in Healthy Subjects.

Nutrients·2023
Same author

Proteins as Mediators of the Association Between Diet Quality and Incident Cardiovascular Disease and All-Cause Mortality: The Framingham Heart Study.

Journal of the American Heart Association·2021
Same author

The fruit of <i>Acanthopanax senticosus Harms</i> improves arterial stiffness and blood pressure: a randomized, placebo-controlled trial.

Nutrition research and practice·2020
Same author

Characterization and Validation of an "Acute Aerobic Exercise Load" as a Tool to Assess Antioxidative and Anti-inflammatory Nutrition in Healthy Subjects Using a Statistically Integrated Approach in a Comprehensive Clinical Trial.

Oxidative medicine and cellular longevity·2019
Same author

Dietary intake of <i>n</i>-3 and <i>n</i>-6 polyunsaturated fatty acids in Korean toddlers 12-24 months of age with comparison to the dietary recommendations.

Nutrition research and practice·2019

Related Experiment Video

Updated: Nov 2, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.8K

Higher diet quality relates to decelerated epigenetic aging.

Youjin Kim1, Tianxiao Huan2, Roby Joehanes3

  • 1Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.

The American Journal of Clinical Nutrition
|June 16, 2021
PubMed
Summary

A higher quality diet, measured by the Dietary Approaches to Stop Hypertension (DASH) score, is linked to slower epigenetic aging. This dietary effect on biological aging partially explains how healthy eating promotes a longer lifespan.

Keywords:
DNA methylationall-cause mortalitydiet qualityepigenetic age accelerationsmoking

More Related Videos

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.1K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.7K

Related Experiment Videos

Last Updated: Nov 2, 2025

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

4.8K
Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.1K
Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans
10:08

Surveying Low-Cost Methods to Measure Lifespan and Healthspan in Caenorhabditis elegans

Published on: May 18, 2022

3.7K

Area of Science:

  • Epigenetics and Aging Research
  • Nutritional Epidemiology
  • Biomarkers of Aging

Background:

  • DNA methylation-based epigenetic age measures serve as biological aging markers associated with healthy lifespan.
  • Limited population-based studies have explored the connection between diet and epigenetic age acceleration.

Purpose of the Study:

  • To investigate the relationship between diet quality and epigenetic age acceleration.
  • To examine how diet influences biological aging markers.

Main Methods:

  • Analysis of data from 1995 participants in the Framingham Heart Study Offspring Cohort.
  • Cross-sectional assessment of the Dietary Approaches to Stop Hypertension (DASH) score against three epigenetic age acceleration measures: Dunedin Pace of Aging Methylation (DunedinPoAm), GrimAge acceleration (GrimAA), and PhenoAge acceleration (PhenoAA).
  • Mediation analysis to evaluate the role of epigenetic age acceleration in the association between DASH score and all-cause mortality.

Main Results:

  • A higher DASH score was significantly associated with lower levels of DunedinPoAm, GrimAA, and PhenoAA.
  • All three epigenetic measures mediated the association between DASH score and all-cause mortality.
  • An interaction between DASH score and smoking status was observed, with stronger associations in ever-smokers.

Conclusions:

  • Higher diet quality correlates with slower epigenetic age acceleration, partially explaining diet's benefits for lifespan.
  • These findings underscore the importance of adopting a healthy diet for healthy aging.
  • Epigenetic age acceleration is a key mechanism linking diet quality to mortality outcomes.