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Updated: Nov 2, 2025
The Use of Gas Chromatography to Analyze Compositional Changes of Fatty Acids in Rat Liver Tissue during Pregnancy
Published on: March 13, 2014
Ursodeoxycholic acid in the treatment of pregnancy cholestasis: a data-set available for Meta-analyses
Ugo Indraccolo1, Chiara Carol Corleto2, Giusi Natalia Milazzo2
1Maternal and Fetal Department, Complex Operative Unit of Obstetrics and Gynecology, "Alto Tevere" Hospital of Città di Castello, ASL I Umbria, Città di Castello, Italy.
Background:
The recent literature on intrahepatic cholestasis of pregnancy raises questions on the best management of such a disease. Improved evidence might be achieved by meta-analyses.
Aim:
Providing data for allowing individual patients meta-analyses and aggregate data meta-analyses.
Methods:
Data were collected retrospectively at the Fabia Mater Hospital of Rome (Italy), between 2013 and 2018. Several variables were collected and analyzed according to low-level bile acid (less than 40 μmol/L) and high-level bile acid (at least 40 μmol/L). Eighty-three cases of pregnancy cholestasis, diagnosed according to itching symptoms and excluding bile diseases, were collected and analyzed, both descriptively and inferentially.
Conclusion:
The analyzed data do not provide significant evidence supporting the use of ursodeoxycholic acid to prevent composite adverse fetal outcomes but they can be included in further meta-analyses.
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