Network analysis of potential risk genes for psoriasis

Area of Science:

• Dermatology
• Immunology
• Genetics

Background:

• Psoriasis is a complex chronic inflammatory skin disease.
• Understanding its genetic and molecular underpinnings is crucial for effective management.

Purpose of the Study:

• To identify potential risk genes and molecular mechanisms associated with psoriasis.
• To explore gene expression and methylation patterns in psoriatic skin.

Main Methods:

• Analysis of gene expression datasets (GSE54456, GSE114286, GSE121212) to identify differentially expressed genes (DEGs).
• Enrichment analysis and protein-protein interaction (PPI) network construction to identify hub genes.
• Logistic regression and nomogram analysis to evaluate gene risk for psoriasis.
• Analysis of methylation data (GSE115797) to identify methylation markers.

Main Results:

• 118 common DEGs were identified, primarily linked to keratinocyte differentiation and the IL-17 signaling pathway.
• CXCL9 and SPRR1B were identified as potential risk factors for psoriasis based on high expression and hub gene analysis.
• TGM6 and S100A9 were associated with increased psoriasis risk, supported by nomogram analysis and methylation markers.

Conclusions:

• Immune and inflammatory responses are active in the keratinocytes of psoriatic skin.
• CXCL9, SPRR1B, TGM6, and S100A9 represent potential diagnostic and therapeutic targets for psoriasis.