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Vasoactive Peptides: Role in COVID-19 Pathogenesis and Potential Use as Biomarkers and Therapeutic Targets

Pariya Khodabakhsh1, Afsaneh Asgari Taei2, Moein Mohseni3

  • 1Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Archives of Medical Research
|June 17, 2021
PubMed

Insights

Vasoactive peptides are crucial for monitoring coronavirus disease 2019 (COVID-19) patients and can be therapeutic targets. Assessing these peptides aids in managing cardiovascular injuries associated with SARS-CoV-2 infection.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Pharmacology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes global health challenges, overwhelming healthcare systems.
  • Beyond respiratory issues, COVID-19 patients frequently exhibit cardiovascular complications.
  • Vasoactive peptides are key regulators in physiological and pathological processes.

Purpose of the Study:

  • To review the role of specific vasoactive peptides in COVID-19.
  • To explore their potential as therapeutic targets and prognostic biomarkers.
  • To discuss peptides including Angiotensin II, VIP, ET-1, CGRP, natriuretic peptides, SP, and BK.

Main Methods:

  • Literature review of existing studies on vasoactive peptides and COVID-19.
  • Analysis of physiological and pathological roles of selected peptides.
  • Synthesis of evidence regarding their clinical implications.

Main Results:

  • Vasoactive peptides are implicated in the cardiovascular manifestations of COVID-19.
  • These peptides show potential as indicators for disease severity and patient outcomes.
  • Specific peptides may offer novel targets for therapeutic intervention.

Conclusions:

  • Routine assessment of vasoactive peptides is recommended for COVID-19 patient monitoring.
  • Vasoactive peptides represent promising therapeutic targets for managing COVID-19.
  • Further research is needed to fully elucidate their clinical utility.
Abstract

Keywords:
Angiotensin IICOVID-19SARS-CoV-2Vasoactive peptides

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