Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Rapid personalisation of cardiovascular models using invasively measured right ventricular pressure.

Computers in biology and medicine·2026

Same author

Dilated Odontoma of the Mandible: A Rare Case Report with Discussion about the Differential Diagnosis.

Journal of dentistry (Shiraz, Iran)·2026

Same author

Ordering molecular diversity in untargeted metabolomics via molecular community networking.

Cell reports methods·2026

Same author

Protocol for constructing correlation-based molecular networks from large-scale untargeted metabolomics data.

bioRxiv : the preprint server for biology·2026

Same author

Tongue Sarcoidosis: A Rare Case Report and Review of the Literature.

Clinical case reports·2026

Same author

S'Wipe: user-friendly stool collection for high-throughput gut metabolomics and multi-omics.

mSystems·2026

Same journal

Translational profiling of Drd2-expressing populations reveals molecular heterogeneity of dentate gyrus mossy cells along the dorsoventral axis.

eNeuro·2026

Same journal

Movement Disorder Patients with Depression have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss.

eNeuro·2026

Same journal

Ocular speech tracking persists in blindness, but its dynamics and oculo-cerebral connectivity depend on visual status.

eNeuro·2026

Same journal

Emergent multidien cycles from partial circadian synchrony.

eNeuro·2026

Same journal

Adolescent social isolation induces persistent impairments in emotional discrimination and helping behavior.

eNeuro·2026

Same journal

Increased Ih Current Is Associated with Reduced Hippocampal CA1 Excitability in a Mouse Model of Multiple Sclerosis.

eNeuro·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 2, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

The HexMaze: A Previous Knowledge Task on Map Learning for Mice.

Alejandra Alonso¹, Levan Bokeria¹, Jacqueline van der Meij¹

¹Donders Institute for Brain, Behaviour and Cognition, Radboud University, 6500 GL, Nijmegen, The Netherlands.

|June 17, 2021

Summary

This summary is machine-generated.

Mice build spatial maps by integrating new information with existing knowledge. Learning speed depends on the time elapsed between training sessions, not the frequency of training, demonstrating a long-term memory effect.

Keywords:

cognitive map memory consolidation navigation schema spatial

More Related Videos

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Published on: December 2, 2022

Related Experiment Videos

Last Updated: Nov 2, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

An Appetitive Spatial Working Memory Task for Mice in a Semi-Automated 8-Arm Radial Maze, Reducing Fearful Memory Association in the Maze

Published on: July 29, 2025

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Utilizing a Reconfigurable Maze System to Enhance the Reproducibility of Spatial Navigation Tests in Rodents

Published on: December 2, 2022

Area of Science:

Neuroscience
Cognitive Science
Animal Behavior

Background:

Knowledge acquisition is influenced by prior learning and cognitive maps.
Spatial learning is crucial for navigation and survival.

Purpose of the Study:

To investigate how mice learn large spatial maps over extended periods.
To determine the role of previous knowledge in spatial learning.
To identify the phases of spatial map acquisition.

Main Methods:

Developed the HexMaze, a novel spatial navigation task in a gangway maze.
Analyzed mouse performance across multiple training sessions and trials.
Assessed learning and memory effects over short and long durations (weeks).

Main Results:

Previous spatial knowledge significantly accelerates learning and performance.
Identified three learning phases: initial goal acquisition, faster relearning, and one-session learning.
Demonstrated a long-term memory effect after 12 weeks.

Conclusions:

Spatial map formation depends on the elapsed time between training, not training frequency.
This highlights the importance of consolidation periods for long-term spatial memory.
The study provides new insights into the dynamics of spatial learning and memory consolidation.