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Relationship between Apgar scores and long-term cognitive outcomes in individuals with Down syndrome

Laura Del Hoyo Soriano1, Tracie C Rosser2, Debra R Hamilton2

  • 1Department of Psychiatry and Behavioral Sciences, MIND Institute University of California Davis, Sacramento, CA, USA. ldelhoyo@ucdavis.edu.

Scientific Reports
|June 17, 2021
PubMed

Insights

A lower Apgar score at 1 minute after birth is linked to poorer cognitive function in individuals with Down syndrome. A lower 5-minute Apgar score also impacts verbal and auditory working memory.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • The Apgar score is a rapid assessment of a newborn's health.
  • Down syndrome is associated with cognitive impairments.
  • The relationship between early Apgar scores and long-term cognitive outcomes in Down syndrome requires further investigation.

Purpose of the Study:

  • To investigate the association between Apgar scores at 1 and 5 minutes after birth and later cognitive functioning in individuals with Down syndrome.

Main Methods:

  • Cognitive assessments were conducted on 168 individuals with Down syndrome aged 6–25 years.
  • The study analyzed the correlation between Apgar scores (at 1 and 5 minutes) and various cognitive measures.

Main Results:

  • A lower 1-minute Apgar score correlated with poorer performance in receptive vocabulary, verbal comprehension and production, visual memory, and working memory.
  • A lower 5-minute Apgar score was associated with worse outcomes in verbal comprehension and production, and auditory working memory.

Conclusions:

  • Early Apgar scores may serve as an indicator for later cognitive development in individuals with Down syndrome.
  • Further research is needed to understand the specific perinatal factors influencing cognitive outcomes in this population.

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