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Related Experiment Video

Updated: Nov 2, 2025

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach

Published on: December 7, 2016

Comparison of Two Different Intravitreal Injection Techniques.

Harvey S Uy^1,2,3, Jose Carlo M Artiaga⁴

¹Department of Ophthalmology and Visual Sciences, University of the Philippines, Manila, Philippines.

Clinical Ophthalmology (Auckland, N.Z.)

|June 17, 2021

Summary

The intravitreal injection guide (IIG) significantly reduces procedure time and subconjunctival hemorrhage compared to the dual blade speculum (DBS) technique for intravitreal medications, with improved patient preference.

Keywords:

aflibercept anti-vascular endothelial growth factor bevacizumab intravitreal injection intravitreal injection guide ranibizumab

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Last Updated: Nov 2, 2025

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Area of Science:

Ophthalmology
Retinal Diseases
Ophthalmic Surgery

Background:

Intravitreal injections (IVI) are crucial for treating various retinal conditions.
Standard techniques include the dual blade speculum plus surgical caliper (DBS).
Novel devices like the intravitreal injection guide (IIG) aim to improve IVI procedures.

Observation:

A randomized clinical trial compared the IIG and DBS techniques in 200 adult eyes.
Procedure time, successful administration, patient preference, and adverse events were evaluated.
All IVI procedures were successfully completed in both groups.

Findings:

The IIG technique resulted in a significantly shorter mean procedure time (9.94s vs. 21.85s).
The incidence of post-injection subconjunctival hemorrhage was lower with the IIG.
Patients with prior IVI experience preferred the IIG over the DBS.

Implications:

The IIG offers a potentially more efficient and comfortable alternative for intravitreal medication delivery.
Reduced procedure time and complications may enhance patient outcomes and satisfaction.
Further studies could explore the long-term benefits and broader adoption of the IIG.