Related Experiment Video
Updated: Nov 2, 2025
05:10
Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
9.9K
Anthelmintics for drug repurposing: Opportunities and challenges.
Seyed Ebrahim Alavi1, Hasan Ebrahimi Shahmabadi1
1Department of Microbiology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Summary
Drug repositioning offers a faster, cheaper way to find new cancer treatments. Anthelmintics, repurposed antiparasitic drugs, show promising anticancer effects and are explored for cancer therapy.
Area of Science:
- Oncology
- Pharmacology
- Drug Discovery
Background:
- Drug repositioning leverages existing drug data to reduce development time and costs.
- Anthelmintics, antiparasitic agents, exhibit emerging anticancer properties.
- Repurposing established drugs offers a viable strategy for novel cancer therapies.
Purpose of the Study:
- To review the potential of anthelmintics for repositioning in cancer treatment.
- To discuss the anticancer mechanisms and therapeutic challenges of using anthelmintics.
- To explore strategies for overcoming challenges in integrating anthelmintics into cancer therapy.
Main Methods:
- Literature review of existing studies on anthelmintics.
- Analysis of pharmacokinetic and pharmacodynamic data of anthelmintics.
- Evaluation of proposed anticancer mechanisms and current development status.
Main Results:
- Anthelmintics demonstrate promising anticancer activity in preclinical studies.
- Established pharmacokinetic and toxicity profiles facilitate drug repositioning.
- Various proposed mechanisms underpin the observed anticancer effects of anthelmintics.
Conclusions:
- Anthelmintics represent a promising class of drugs for repositioning in oncology.
- Further research and strategic development are needed to overcome therapeutic challenges.
- Successful repositioning of anthelmintics could offer new avenues for cancer treatment.
Related Concept Videos
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
536
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
536
01:17Drugs for Treatment of Diarrhea-Predominant IBS
388
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
388
01:26Drug Discovery: Overview
10.2K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
10.2K
01:26Cholinergic Antagonists: Therapeutic Uses
1.0K
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.0K
01:18Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
264
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
264
01:02Prescription, Nonprescription and Orphan Drugs
973
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
973