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Updated: Nov 2, 2025
05:02
Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
Published on: October 24, 2019
32.6K
Making fundamental scientific discoveries by combining information from literature, databases, and computational
Bastian Stielow1, Clara Simon1, Robert Liefke1,2
1Institute of Molecular Biology and Tumor Research (IMT), Philipps University of Marburg, 35043 Marburg, Germany.
Computational and Structural Biotechnology Journal
|June 17, 2021
Summary
Researchers identified the protein SAMD1 (SAM domain-containing protein 1) as a novel unmethylated CpG island-binding protein using public data. This highlights both the power and potential pitfalls of internet-based scientific discovery.
Area of Science:
- Molecular Biology
- Bioinformatics
- Genomics
Background:
- The exponential growth of scientific literature, data, and computational tools presents both opportunities and challenges.
- Effective utilization of these resources is crucial for scientific advancement.
- Previously, the protein SAMD1 (SAM domain-containing protein 1) remained largely uncharacterized.
Purpose of the Study:
- To identify novel unmethylated CpG island-binding proteins using publicly available information.
- To characterize the protein SAMD1 (SAM domain-containing protein 1).
- To illustrate the process and challenges of scientific discovery using online resources.
Main Methods:
- Leveraging publicly available scientific literature, databases, and computational tools.
- Bioinformatic analysis to identify potential protein candidates.
- Experimental validation (details not provided in abstract but implied by characterization).
Main Results:
- Identification of SAMD1 (SAM domain-containing protein 1) as a novel unmethylated CpG island-binding protein.
- Demonstration of how public data can lead to significant scientific findings.
- Highlighting potential hurdles, such as misrepresentation of information in literature and databases.
Conclusions:
- Publicly available data and tools can facilitate the discovery of novel biological functions and proteins.
- Misinformation or incomplete data in scientific resources can impede research progress.
- This case study provides valuable lessons for navigating and utilizing the vast landscape of online scientific information.
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