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The Development of Lyophilized Loop-mediated Isothermal Amplification Reagents for the Detection of Coxiella burnetii
Published on: April 18, 2016
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Q Fever Endocarditis in Northeast Iran.
Ali Akbar Heydari1, Ehsan Mostafavi2,3, Masoumeh Heidari1
1Research Center for Infection Control & Hand Hygiene, Mashhad University of Medical Sciences, Mashhad, Iran.
Case Reports in Infectious Diseases
|June 17, 2021
Summary
This case report details a farmer diagnosed with chronic Q fever endocarditis. Prompt diagnosis and treatment with doxycycline and hydroxychloroquine led to successful recovery.
Area of Science:
- Infectious Diseases
- Cardiology
- Microbiology
Background:
- Q fever endocarditis is a rare but serious complication of Coxiella burnetii infection.
- Early diagnosis and treatment are crucial for patient outcomes.
Observation:
- A 60-year-old male farmer presented with non-specific symptoms including weight loss, fever, sweating, weakness, and anorexia.
- Blood PCR for Coxiella burnetii was negative, but high-titer IgG antibodies (Phase I and II) were detected via IFA.
Findings:
- The patient met the adjusted Duke criteria for Q fever endocarditis.
- Diagnosis was confirmed despite negative blood PCR, highlighting the importance of serological testing.
Implications:
- This case underscores the diagnostic challenges of Q fever endocarditis, particularly in its chronic form.
- Successful treatment with doxycycline and hydroxychloroquine demonstrates effective therapeutic options.
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