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Updated: Nov 2, 2025

A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
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Molecular Characterization and Clinical Relevance of Lysine Acetylation Regulators in Urological Cancers

Jian Zhang1, Chunning Zhang2, Huali Jiang3

  • 1Department of Radiation Oncology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, Guangzhou, China.

Frontiers in Oncology
|June 17, 2021
PubMed
Abstract

Insights

Lysine acetylation regulators are altered in urological cancers, impacting cancer pathways and prognosis. These findings offer insights into cancer development and potential therapeutic strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Lysine acetylation and deacetylation are crucial posttranslational modifications linking cellular signals.
  • The role of lysine acetylation regulators in urological cancers remains largely unexplored.

Purpose of the Study:

  • To investigate genetic and expression alterations of lysine acetylation regulators in urological cancers.
  • To explore the correlation between these regulators and cancer pathway activation.
  • To analyze the clinical relevance of lysine acetylation regulators for patient stratification.

Main Methods:

  • Systematic analysis of genetic and expression alterations in 31 lysine acetylation regulators.
  • Exploration of correlations with cancer hallmark pathway activation.
  • Clinical relevance assessment for prognostic stratification.

Main Results:

  • Widespread genetic alterations and significant expression changes of lysine acetylation regulators identified.
  • Expression levels correlate with the activity of cancer hallmark-related pathways.
  • HDAC11 identified as a potential oncogene in cell cycle and oxidative phosphorylation in urological cancers.

Conclusions:

  • Lysine acetylation regulators play a significant role in the tumorigenesis and progression of urological cancers.
  • These regulators are potential biomarkers for prognostic stratification.
  • The study provides a valuable resource for future mechanistic and therapeutic investigations.
Keywords:
cancer pathwaysgenetic alterationslysine acetyltransferaselysine deacetylaseurological cancers

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