Related Experiment Videos
Functioning hepatic cell mass and the hyperdynamic state in cirrhosis
K Ito1, G Ramirez-Schon, P M Shah
1Department of Surgery, New York Medical College, Bronx, New York 10595.
Surgery, Gynecology & Obstetrics
|September 1, 1988
Summary
Advanced hepatic cirrhosis patients show a hyperdynamic circulatory state linked to reduced oxygen consumption. Indocyanine green clearance predicts mortality risk in these patients, offering insights into liver disease severity.
Area of Science:
- Cardiology
- Hepatology
- Critical Care Medicine
Background:
- Advanced hepatic cirrhosis is characterized by a hyperdynamic circulatory state.
- Assessing functioning hepatic cell mass is crucial for patient management.
Purpose of the Study:
- To evaluate the relationship between indocyanine green clearance and hemodynamic parameters in cirrhosis.
- To investigate oxygen consumption in cirrhotic patients with a hyperdynamic state.
- To determine if indocyanine green clearance predicts outcomes in advanced cirrhosis.
Main Methods:
- Seventeen patients with advanced hepatic cirrhosis underwent cardiopulmonary assessment.
- Swan-Ganz catheters were used for hemodynamic monitoring.
- Indocyanine green (ICG) clearance studies measured functioning hepatic cell mass.
Main Results:
- ICG clearance showed a significant linear correlation with cardiac index and total peripheral resistance.
- Cirrhotic patients exhibited limited oxygen consumption compared to controls.
- Mean ICG clearance was a significant predictor of mortality (8/14 survived operations).
Conclusions:
- Indocyanine green clearance is a valuable tool for assessing the hyperdynamic state in cirrhosis.
- The hyperdynamic state in cirrhosis is associated with impaired oxygen utilization.
- ICG clearance serves as a prognostic indicator for survival in advanced hepatic cirrhosis.