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Serum galectin-3 levels in patients with psoriasis
Yıldız Hayran1, Nuran Allı1, Ümit Akpınar1
1Department of Dermatology, Ankara City Hospital, Ankara, Turkey.
International Journal of Clinical Practice
|June 17, 2021
Summary
Elevated serum galectin-3 levels are found in psoriasis patients, suggesting its role in the disease. Higher galectin-3 levels significantly increase psoriasis risk and can predict its presence.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Background:
- Galectin-3 is a lectin linked to inflammation and proliferation, key features of psoriatic skin.
- Psoriasis is a chronic inflammatory skin condition with characteristic cellular proliferation.
Purpose of the Study:
- To compare serum galectin-3 levels in psoriasis patients versus healthy controls.
- To examine the association between serum galectin-3 and psoriasis disease characteristics.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of galectin-3, IL-17, IL-6, and TNF-α.
- The study included 78 psoriasis patients and 78 matched healthy controls.
Main Results:
- Psoriasis patients exhibited significantly higher serum galectin-3, IL-17, IL-6, and TNF-α levels compared to controls.
- A serum galectin-3 level above 10 ng/mL was associated with a 14.5-fold increased risk of psoriasis, showing 83.3% sensitivity and 74.3% specificity.
- No significant correlation was found between serum galectin-3 levels and disease severity, psoriatic arthritis, nail involvement, comorbidities, or other inflammatory markers.
Conclusions:
- Elevated serum galectin-3 may play a role in the pathogenesis of psoriasis.
- Serum galectin-3 could serve as a potential biomarker for psoriasis detection.
