Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.2K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.2K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

5.2K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
5.2K
Bone Remodeling01:40

Bone Remodeling

39.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
39.0K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.5K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.5K
Bone Disorders01:29

Bone Disorders

4.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.5K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

3.1K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
3.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urinary protein vs albumin for assessing kidney failure risk in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

Evaluation of the Association between Age, Sex and d-Amino Acid-Based Estimation of Glomerular Filtration Rate.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Clinical Evaluation of the Clinical Reasoning Process of Large Language Models in Nephrology: Comparative Evaluation Study.

JMIR formative research·2026
Same author

Acute decline in kidney function during treatment for malignancy: a single center retrospective cohort study.

Journal of nephrology·2026
Same author

SGLT2 inhibitors and urinary tract infections: resolving the dilemma through aetiological classification.

European heart journal·2026
Same author

Design of the Japan Kidney Association-Pemafibrate Intervention for Chronic Kidney Disease patients Study (JKAPI-CKD Study).

Clinical kidney journal·2026

Related Experiment Video

Updated: Nov 1, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K

Exercise-induced hypercalcemia and vasopressin-mediated bone resorption.

M Senda1,2, T Hamano3,4, N Fujii5

  • 1Health Care Division, Health and Counseling Center, Osaka University, Osaka, Japan.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|June 17, 2021
PubMed
Summary
This summary is machine-generated.

Heavy exercise can cause hypercalcemia due to increased arginine vasopressin (AVP) and bone resorption. This study links elevated AVP to higher TRACP-5b, a marker of bone resorption, explaining exercise-induced hypercalcemia.

Keywords:
Bone formationCatecholamineDehydrationProcollagen type 1 N propeptideTartrate-resistant acid phosphatase 5bWhole parathyroid hormone

More Related Videos

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

6.7K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.9K

Related Experiment Videos

Last Updated: Nov 1, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.1K
A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

6.7K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.9K

Area of Science:

  • Endocrinology
  • Exercise Physiology
  • Bone Metabolism

Background:

  • Exercise-induced hypercalcemia is not fully understood.
  • Bone resorption may play a role.
  • Arginine vasopressin (AVP) is known to stimulate osteoclast activity.

Purpose of the Study:

  • To investigate the link between heavy exercise, bone resorption markers, and hypercalcemia.
  • To determine the role of arginine vasopressin (AVP) and catecholamines in exercise-induced hypercalcemia.

Main Methods:

  • Prospective observational study of 65 healthy males undergoing 5-hour heavy exercise.
  • Measured bone markers (TRACP-5b, P1NP), catecholamines, AVP, and calcium levels (total and ionized) before and after exercise.
  • Estimated corrected calcium levels post-exercise.

Main Results:

  • 18% of participants developed hypercalcemia post-exercise.
  • Elevated serum TRACP-5b and AVP levels were observed post-exercise.
  • Increased TRACP-5b was associated with AVP, not catecholamines, and positively correlated with calcium levels.
  • Nausea and vomiting were associated with higher post-exercise ionized calcium.

Conclusions:

  • Elevated arginine vasopressin (AVP) following heavy exercise may drive bone resorption.
  • AVP-mediated bone resorption is a likely mechanism for exercise-induced hypercalcemia.