Related Experiment Video
Updated: Nov 1, 2025
10:16
A Protocol for Real-time 3D Single Particle Tracking
Published on: January 3, 2018
15.1K
A Review on Deterministic Lateral Displacement for Particle Separation and Detection
Thoriq Salafi1,2, Yi Zhang2, Yong Zhang3,4
1NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, 119077, Singapore.
Nano-Micro Letters
|June 17, 2021
Summary
Deterministic Lateral Displacement (DLD) offers high-resolution particle separation for medical diagnostics. Recent advancements enhance its performance and expand applications in biomolecule detection and point-of-care diagnostics.
Area of Science:
- Microfluidics
- Biotechnology
- Nanotechnology
Background:
- Particle separation and detection are crucial for medical diagnostics.
- Microfluidic Determinative Lateral Displacement (DLD) is a passive technique for high-resolution particle separation.
- Previous reviews on DLD were published in 2014, necessitating an update.
Purpose of the Study:
- To review recent advancements in DLD technology since 2014.
- To discuss updated physics, new phenomena, and novel designs in DLD.
- To explore emerging clinical applications and biomolecule detection capabilities of DLD.
Main Methods:
- Review of fundamental studies on DLD models.
- Analysis of DLD applications for particle separation and detection.
- Discussion of recent design innovations for improved performance and throughput.
Main Results:
- DLD technology has matured with updated physics and discovered phenomena.
- New designs have been developed for enhanced separation performance and throughput.
- DLD shows promise for biomolecule detection and clinical applications.
Conclusions:
- Recent progress in DLD significantly contributes to particle separation and detection.
- DLD offers rapid, low-cost, and high-throughput solutions for point-of-care diagnostics.
- Further understanding of DLD techniques will drive advancements in various applications.
