Related Experiment Video
Updated: Nov 1, 2025
07:31
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
Published on: December 2, 2016
10.3K
Losartan modifies mesh integration after abdominal wall repair: an experimental study
M E Peña1, C A Angeramo1, F Schlottmann1
1Department of Surgery, Hospital Alemán of Buenos Aires, Av. Pueyrredón 1640, 1118, Buenos Aires, CP, Argentina.
Summary
Losartan, an Angiotensin II receptor blocker, reduced blood pressure and impaired mesh integration in rats. This suggests Losartan may negatively affect tissue-prosthesis interaction after abdominal wall repair.
Area of Science:
- Biomedical Engineering
- Surgical Research
- Pharmacology
Background:
- Angiotensin II (AT II) receptor blockers are known to reduce inflammatory responses.
- Understanding their impact on surgical repair is crucial for optimizing patient outcomes.
Purpose of the Study:
- To investigate the effects of the AT II receptor blocker, Losartan, on mesh integration following abdominal wall repair in a rat model.
- To assess Losartan's influence on both normotensive and hypertensive rats.
Main Methods:
- A ventral hernia and polypropylene mesh repair was performed on Wistar-Kyoto (WKY) and spontaneously hypertensive stroke-prone (SHRSP) rats.
- Rats received either saline or Losartan (40 mg/kg) postoperatively.
- Macroscopic and microscopic evaluations were conducted 30 days post-surgery, utilizing H&E and Masson's trichrome staining.
Main Results:
- Losartan significantly reduced blood pressure in both WKY and SHRSP rats.
- Macroscopic analysis revealed significantly reduced mesh incorporation and adherence in Losartan-treated groups.
- Microscopic examination showed increased immature fibroplasia and decreased scar plate formation and inflammatory response with Losartan treatment.
Conclusions:
- Losartan alters the host tissue-prosthesis interaction.
- Impaired mesh integration and immature fibroplasia were observed in both normotensive and hypertensive rats treated with Losartan.
- Further research is warranted to fully understand these effects in abdominal wall repair.
