[Oxidative phosphorylation in the brain in myocardial necrosis. The effect of emotional stress]

The formation of ischemic myocardium necrosis is accompanied by a disturbance of respiratory and phosphorylating function in the cortex of cerebral hemispheres. In this case the most considerable changes are revealed with the use of alpha-ketoglutarate as an oxidation substrate. Inhibition of succinic acid oxidation arises only when the acute stage of the experiment comes to an end (by the 7th day). Development of ischemic myocardium necrosis after the endured stress results in deeper inhibition of mitochondrial respiration of cerebral hemispheres.