[New Armed Antibody"ADC: Antibody-Drug Conjugate"for Solid Tumor]

Armed antibodies, of which are representative antibody-drug conjugate(ADC)and radioimmunotherapy(RIT), are attracting attention as next-generation antibody drugs with high efficacy and low side effects. Armed antibodies require clinically optimized adaptation and development strategies, in addition to the fusion of basic technologies such as organic chemistry, protein chemistry, imaging technology, structural biology, and biomarker research. In armed antibodies, the antibody is only a carrier for deliver and its therapeutic effect affects the specificity/strength of the payload, which is the effector agent for target molecules on cell surface. An ADC with a bystander effect is a promising drug for solid tumors with heterogeneous target molecule expression. Aside from the next-generation ADC DS8201, new ADCs are being developed at an accelerated pace, demonstrating new therapeutic possibilities. In the future, it will be necessary to optimize predictors of therapeutic effect based on the MOA of ADC.