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Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Nov 1, 2025

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Author Spotlight: Innovative Use of nsPEF to Boost Peripheral Nerve Regeneration

Published on: May 3, 2024

Evolving Techniques in Peripheral Nerve Regeneration.

Steven T Lanier¹, J Ryan Hill¹, Christopher J Dy²

¹Department of Orthopaedic Surgery, Washington University in St. Louis, St. Louis, MO.

The Journal of Hand Surgery

|June 18, 2021

Summary

This summary is machine-generated.

Peripheral nerve regeneration after injury is challenging. Current strategies like molecular therapies and electrical stimulation show promise in animal models and early clinical trials for improving functional recovery.

Keywords:

Electrical stimulation SARM-1 nerve regeneration peripheral nerve

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Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

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Last Updated: Nov 1, 2025

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Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration

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Published on: February 26, 2015

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

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Published on: October 20, 2021

Area of Science:

Neuroscience
Regenerative Medicine
Surgical Innovation

Background:

Peripheral nerve injuries significantly impair function.
Achieving complete nerve regeneration and functional recovery remains a major clinical challenge.
Wallerian degeneration impedes natural nerve repair processes.

Purpose of the Study:

To review current strategies for enhancing peripheral nerve regeneration.
To evaluate the potential of novel therapeutic approaches in preclinical and early clinical settings.
To highlight advancements in mitigating nerve injury consequences and promoting functional restoration.

Main Methods:

Review of molecular therapies targeting Wallerian degeneration.
Analysis of electrical stimulation and gene therapy for axonal regeneration enhancement.
Exploration of alternative nerve repair techniques, such as tissue fusion.

Main Results:

Various strategies demonstrate potential in preclinical animal studies.
Early clinical trials indicate promise for improved functional outcomes.
No single method has yet fully overcome the complexities of nerve repair.

Conclusions:

Despite challenges, significant progress is being made in peripheral nerve regeneration.
A combination of therapeutic approaches may offer the best path forward.
Continued research is crucial for translating promising findings into effective clinical treatments.