Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand Binding Sites02:40

Ligand Binding Sites

14.3K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
14.3K
Ligand Binding Sites02:40

Ligand Binding Sites

8.2K
8.2K
Protein Organization01:24

Protein Organization

8.1K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
8.1K
Protein Organization01:13

Protein Organization

151.3K
Overview
151.3K
Protein-protein Interfaces02:04

Protein-protein Interfaces

14.1K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.1K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

4.1K
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practice Environment and Job Outcomes Among Primary Care Nurse Practitioners Caring for Patients With Dementia.

Journal of the American Geriatrics Society·2026
Same author

The associations between maternal disability and perinatal outcomes among Black and/or Hispanic women in PRAMS.

BMC pregnancy and childbirth·2026
Same author

Psychometric evaluation of the Spanish-language version of the health information technology usability evaluation scale (Health-ITUES).

International journal of medical informatics·2026
Same author

Discovery and Cryo-EM-Guided Development of a Neuropilin-2-Binding Aptamer for Receptor Antagonism.

Journal of the American Chemical Society·2026
Same author

Cooperativity, entropy, and effective concentration in DNA origami self-replication.

Science advances·2026
Same author

Imaging Lipid-Associated Macromolecular Structures by Optimized Negative-Staining Transmission Electron Microscopy.

Methods in molecular biology (Clifton, N.J.)·2026

Related Experiment Video

Updated: Nov 1, 2025

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.1K

Designed and biologically active protein lattices.

Shih-Ting Wang1, Brian Minevich2, Jianfang Liu3

  • 1Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, NY, USA.

Nature Communications
|June 18, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed DNA-based voxels to precisely organize proteins into 2D and 3D arrays. This enables the creation of functional protein nanomaterials with tailored structures and biological activity.

More Related Videos

Designing Silk-silk Protein Alloy Materials for Biomedical Applications
11:14

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Published on: August 13, 2014

18.6K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.2K

Related Experiment Videos

Last Updated: Nov 1, 2025

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer
10:34

Ligand Nano-cluster Arrays in a Supported Lipid Bilayer

Published on: April 23, 2017

7.1K
Designing Silk-silk Protein Alloy Materials for Biomedical Applications
11:14

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

Published on: August 13, 2014

18.6K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.2K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Structural Biology

Background:

  • Organizing proteins in space is crucial for advanced biomaterials and nanoscale systems.
  • Current methods lack the precision needed for complex, ordered protein arrangements.

Purpose of the Study:

  • To demonstrate a method for creating ordered protein arrays using DNA-based voxels.
  • To achieve precise 2D and 3D organization of proteins for functional applications.

Main Methods:

  • Encapsulating proteins within DNA-based voxels.
  • Programmable assembly of voxels into ordered protein arrays.
  • Characterization using in situ X-ray scattering and cryo-electron microscopy.

Main Results:

  • Successfully formed single-layer, double-layer, and 3D protein lattices using ferritin and apoferritin.
  • Demonstrated control over protein organization through voxel design and inter-voxel encoding.
  • Confirmed structural stability and biological activity of the assembled protein arrays.

Conclusions:

  • DNA-based voxels provide a versatile platform for engineering ordered protein nanomaterials.
  • The developed method enables precise control over protein arrangement for bio-active applications.
  • This approach opens possibilities for cell-free systems and hybrid nanoscale devices.