Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Polygenic Traits01:18

Polygenic Traits

67.3K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
67.3K
Human Genetics01:28

Human Genetics

936
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
936
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.8K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.8K
Incomplete Dominance01:43

Incomplete Dominance

28.3K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
28.3K
Biostatistics: Overview01:20

Biostatistics: Overview

435
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
435

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular genetic influences on sustained attention and executive processes and their links with psychopathology in the AFFECT study.

Molecular psychiatry·2026
Same author

Are there sex differences in the influence of insomnia symptoms and sleep duration on the trajectory of neuromuscular strength decline?

Age and ageing·2026
Same author

How social, psychological, and spiritual needs are supported in the last months of life: evidence from the English Longitudinal Study of Ageing end-of-life interviews.

Age and ageing·2026
Same author

Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.

bioRxiv : the preprint server for biology·2026
Same author

Changes in heritability and shared environmentality of educational attainment across twentieth-century Norway.

Nature communications·2026
Same author

Adherence to the Mediterranean diet and psychological wellbeing before and during the COVID-19 pandemic: a prospective analysis of the English Longitudinal Study of Ageing.

BMJ open·2026

Related Experiment Video

Updated: Nov 1, 2025

Eukaryotic Polyribosome Profile Analysis
09:16

Eukaryotic Polyribosome Profile Analysis

Published on: June 15, 2010

52.9K

Resource profile and user guide of the Polygenic Index Repository.

Joel Becker1, Casper A P Burik2, Grant Goldman3

  • 1Department of Economics, New York University, New York, NY, USA.

Nature Human Behaviour
|June 18, 2021
PubMed
Summary

Polygenic indexes (PGIs) are DNA-based predictors now available for 47 phenotypes. A new framework helps interpret PGIs, addressing errors-in-variables bias in genetic research.

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.2K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.0K

Related Experiment Videos

Last Updated: Nov 1, 2025

Eukaryotic Polyribosome Profile Analysis
09:16

Eukaryotic Polyribosome Profile Analysis

Published on: June 15, 2010

52.9K
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.2K
Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.0K

Area of Science:

  • Genetics
  • Bioinformatics
  • Statistical Genetics

Background:

  • Polygenic indexes (PGIs) are increasingly valuable DNA-based predictors in scientific research.
  • Accurate PGIs are crucial for advancing genetic studies across various disciplines.

Purpose of the Study:

  • To construct and provide a comprehensive resource of PGIs for 47 phenotypes across 11 datasets.
  • To develop a theoretical framework for interpreting PGI analyses and addressing associated biases.
  • To offer a practical tool for correcting errors-in-variables bias in PGI-based regressions.

Main Methods:

  • Consistent methodology applied to construct PGIs for 47 phenotypes in 11 diverse datasets.
  • Utilized genome-wide association studies (GWAS) from multiple sources, including 23andMe and UK Biobank, to maximize prediction accuracy.
  • Developed a theoretical framework and derived a bias-correction estimator for PGI analyses.

Main Results:

  • Successfully constructed PGIs for 47 phenotypes, enhancing their utility for researchers.
  • Established that PGIs can be viewed as noisy measures of an 'additive SNP factor', leading to errors-in-variables bias.
  • Derived and demonstrated a method to correct for this bias in statistical models.

Conclusions:

  • The developed PGIs provide a valuable resource for genetic research.
  • The theoretical framework and bias-correction method improve the interpretability and accuracy of PGI-based analyses.
  • A publicly available Python tool facilitates the implementation of bias correction in research.