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Related Concept Videos

Complementation Tests00:49

Complementation Tests

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A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
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Testing a Claim about Population Proportion01:24

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A complete procedure for testing a claim about a population proportion is provided here.
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
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Related Experiment Video

Updated: Nov 1, 2025

Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses
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Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses

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Proficiency testing and ring trials.

P Johnson, L Cabuang

    Revue Scientifique Et Technique (International Office of Epizootics)
    |June 18, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Proficiency testing (PT) programs are crucial for validating diagnostic methods and ensuring laboratory quality assurance. Participation in PT supports method life cycle management and assesses assay performance, especially for novel diagnostics like SARS-CoV-2 tests.

    Keywords:
    Method validationProficiency testingVerification

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    Area of Science:

    • Clinical diagnostics
    • Laboratory quality assurance
    • Infectious disease control

    Background:

    • Inter-laboratory comparisons (IC), including proficiency testing (PT) programs, are essential for validating diagnostic methods and laboratory results.
    • Compliance with international quality standards necessitates ongoing participation in PT programs to ensure continuous method validation and fitness assessment.
    • PT panel designs challenge diagnostic specificity and sensitivity, providing insights into assay performance and laboratory stability over time.

    Purpose of the Study:

    • To highlight the critical role of proficiency testing in maintaining and improving the quality of diagnostic methods.
    • To emphasize the importance of PT for assessing the performance of both established and novel diagnostic technologies.
    • To advocate for increased resources to enhance the quality and accessibility of PT programs.

    Main Methods:

    • Review of the role and impact of inter-laboratory comparisons and proficiency testing in laboratory settings.
    • Analysis of how PT programs support method validation, life cycle management, and quality assurance.
    • Discussion of the application of PT to emerging diagnostic technologies and infectious diseases, such as SARS-CoV-2.

    Main Results:

    • Proficiency testing is integral to laboratory quality assurance, supporting method validation and performance monitoring.
    • PT programs are vital for assessing the fitness of diagnostic assays, including novel technologies like whole genome sequencing and point-of-care tests.
    • Participation in PT is essential for understanding and ensuring the reliability of assays, particularly for emerging infectious diseases like SARS-CoV-2.

    Conclusions:

    • Proficiency testing remains a cornerstone of laboratory quality assurance, essential for validating diagnostic methods.
    • Investment in high-quality PT programs, including accessible materials, is crucial for supporting both existing and new diagnostic technologies.
    • PT programs are indispensable for ensuring the accuracy and reliability of diagnostic testing, particularly in the context of infectious disease control and emerging health threats.