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Microfluidics in Assessing Platelet Function

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Elevated Platelet Distribution Width Predicts Poor Prognosis in Gallbladder Carcinoma.

Fei Liu¹, Hai-Jie Hu¹, Parbatraj Regmi¹

¹Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan Province, People's Republic of China.

Cancer Management and Research

|June 18, 2021

Summary

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Elevated platelet distribution width (PDW) is a significant predictor of poor prognosis in gallbladder carcinoma (GBC) patients. This finding highlights PDW as a potential biomarker for GBC outcomes.

Area of Science:

Oncology
Hematology

Background:

Platelet distribution width (PDW) is recognized as a prognostic indicator in various cancers.
The prognostic significance of PDW in gallbladder carcinoma (GBC) has not been previously established.

Purpose of the Study:

To investigate the association between PDW and prognosis in patients diagnosed with GBC.
To determine if PDW can serve as a predictive biomarker for GBC outcomes.

Main Methods:

Analysis of clinicopathological features and PDW levels in 303 GBC patients who underwent curative surgery.
Utilized Receiver Operating Characteristic (ROC) curve analysis to determine the optimal PDW cutoff value.
Employed Kaplan-Meier survival analysis and Cox regression models to assess overall survival (OS) and identify independent prognostic factors.

Keywords:

gallbladder carcinoma platelet distribution width prognosis

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Main Results:

A significant correlation was observed between elevated PDW and advanced AJCC stage in GBC patients.
Patients with higher PDW levels (PDW > 14.95) exhibited significantly worse overall survival (P < 0.001).
Multivariable Cox regression confirmed PDW as an independent prognostic factor for GBC (HR=1.976, P<0.001).

Conclusions:

Elevated PDW is a reliable predictor of poor prognosis in patients with gallbladder carcinoma.
Further research is warranted to validate these findings and elucidate the underlying molecular mechanisms of PDW in GBC.