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Related Concept Videos

Dialysis01:15

Dialysis

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Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
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Overview Of Cell Separation And Isolation01:20

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Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.
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Related Experiment Video

Updated: Nov 1, 2025

Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
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Nanofiltration membrane for bio-separation: Process-oriented materials innovation.

Yang Cao1,2, Guoqiang Chen1, Yinhua Wan1,2

  • 1State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing P. R. China.

Engineering in Life Sciences
|June 18, 2021
PubMed
Summary
This summary is machine-generated.

Nanofiltration (NF) membranes offer efficient, low-cost bio-separation but face challenges in selectivity and fouling. This review highlights material innovations to improve NF performance for bio-product purification and industrialization.

Keywords:
interfacial polymerizationmembrane foulingmembrane separationnanomaterialspolymeric membranes

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Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Materials Science

Background:

  • Nanofiltration (NF) is increasingly utilized for bio-separation due to its efficiency and cost-effectiveness.
  • Current NF applications are hindered by limitations in molecular selectivity, chemical stability, and membrane fouling.
  • Significant research is directed towards developing advanced NF materials to overcome these challenges.

Purpose of the Study:

  • To review recent advancements in Nanofiltration (NF) applications for bio-separation.
  • To discuss the specific requirements for NF membranes in bio-product purification.
  • To explore material innovations addressing NF limitations in bio-separation processes.

Main Methods:

  • Literature review of recent progress in NF materials and applications for bio-separation.
  • Analysis of demands for NF membranes in bio-product purification.
  • Synthesis of information on material innovations and their impact on NF performance.

Main Results:

  • Nanofiltration (NF) shows promise for bio-separation, but material limitations impede large-scale use.
  • Innovations in NF membrane materials are crucial for enhancing molecular selectivity and reducing fouling.
  • Improved membrane design can increase bio-product separation efficiency and membrane lifespan.

Conclusions:

  • Further research and development in NF materials are essential for advancing bio-separation technologies.
  • Material innovations can lead to more efficient, cost-effective, and durable NF membranes for industrial bio-product purification.
  • This review provides guidance for future product development and process industrialization in NF-based bio-separation.