Related Experiment Video
Updated: Nov 1, 2025
12:17
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
10.9K
O-GlcNAcylation in Hyperglycemic Pregnancies: Impact on Placental Function
Jie Ning1,2,3, Huixia Yang1,2,3
1Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China.
Frontiers in Endocrinology
|June 18, 2021
Summary
O-GlcNAcylation, a protein modification, impacts placental function during pregnancy. Elevated levels in hyperglycemia may affect offspring development, highlighting therapeutic potential.
Area of Science:
- Biochemistry
- Cellular Biology
- Reproductive Medicine
Background:
- O-GlcNAcylation is a dynamic post-translational modification regulating cellular processes.
- It is controlled by O-GlcNAc transferase and O-GlcNAcase.
- O-GlcNAcylation modulates placental function and is altered in pregnancies with hyperglycemia.
Purpose of the Study:
- To review the impact of O-GlcNAcylation on placental functions in hyperglycemia-associated pregnancies.
- To explore the association between O-GlcNAcylation, placental development, and hyperglycemia.
- To examine O-GlcNAcylation's role in nutrient transport and inflammation.
Main Methods:
- Literature review focusing on O-GlcNAcylation in placental biology.
- Analysis of existing research on hyperglycemia during pregnancy.
- Discussion of molecular pathways involved in O-GlcNAcylation.
Main Results:
- Increased O-GlcNAcylation in placental tissues is linked to hyperglycemia in pregnancy.
- O-GlcNAcylation influences placental development and nutrient transport (e.g., glucose).
- O-GlcNAcylation exhibits a dual role in regulating placental inflammation.
Conclusions:
- Altered O-GlcNAcylation in the placenta during hyperglycemic pregnancies affects offspring's near- and long-term development.
- Understanding these mechanisms offers significant therapeutic opportunities.
- Further research is crucial for developing interventions targeting O-GlcNAcylation.
More Related Videos
06:11Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
Published on: May 17, 2024
859
05:31Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
1.0K
Related Concept Videos
01:20Pathophysiology of Diabetes
2.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.2K
01:22Diabetes Mellitus: Type 2 and Gestational
3.6K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.6K
01:27Glucose Transporters
26.3K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
26.3K
01:15Hypoglycemia and Glucagon
496
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
496
01:05Proteoglycans
4.2K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
4.2K
01:19Overview of Carbohydrate Metabolism
2.4K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
2.4K