Bilateral Primary testicular diffuse large B-CELL lymphoma

Area of Science:

• Oncology
• Hematology
• Pathology

Background:

• Primary testicular lymphoma (PTL) is an uncommon extranodal non-Hodgkin lymphoma.
• It represents the most frequent testicular malignancy in elderly individuals.
• PTL is known for its aggressive behavior, propensity for extranodal spread (particularly to the central nervous system), high recurrence rates, and poor prognosis.

Observation:

• A 55-year-old male presented with advanced bilateral PTL.
• The patient exhibited no specific presenting symptoms.
• The diagnosis was confirmed through clinical and pathological evaluation.

Findings:

• The case involved bilateral involvement of the testes by lymphoma.
• Advanced stage disease was present despite the absence of overt symptoms.
• A comprehensive multimodal treatment strategy was initiated.

Implications:

• This case underscores the importance of considering PTL in the differential diagnosis of testicular masses, even in the absence of typical symptoms.
• Multimodal therapy may offer a viable treatment option for advanced bilateral PTL.
• Further research into optimal treatment strategies for this rare and aggressive lymphoma is warranted.