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Transient immune hepatitis as post-coronavirus disease complication: A case report
Anca Cristina Drăgănescu1, Oana Săndulescu1, Anuța Bilașco1
1Infectious Diseases Department, National Institute for Infectious Diseases "Prof. Dr. Matei Balș", Bucharest 021105, Romania.
World Journal of Clinical Cases
|June 18, 2021
Summary
A young man developed immune hepatitis after mild coronavirus disease (COVID-19). This post-COVID complication resolved spontaneously, highlighting the need for vigilance in young patients.
Area of Science:
- Hepatology
- Immunology
- Infectious Diseases
Background:
- Presents a rare case of immune hepatitis following mild coronavirus disease (COVID-19).
- Highlights a potential post-infectious complication in young adults without prior health issues.
Observation:
- A 21-year-old male experienced elevated liver enzymes (ALT, AST) 20 days post-COVID-19 remission.
- Hepatobiliary enzyme elevation peaked at 15x upper limit of normal, with preserved liver function.
- Liver enzyme dynamics correlated with rising SARS-CoV-2 antibody titers.
Findings:
- Diagnosed as post-COVID immune hepatitis after excluding other causes.
- Hepatocytolysis resolved spontaneously within 20 days of peak ALT.
- Anti-SARS-CoV-2 antibodies continued to rise for 5 months post-infection.
Implications:
- Suggests immune-mediated liver injury as a post-COVID-19 complication.
- Emphasizes the importance of monitoring for delayed complications, even after mild SARS-CoV-2 infection.
- Recommends maintaining a high index of suspicion for post-COVID conditions in young individuals.
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