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Updated: Nov 1, 2025

Tubal Cytology of the Fallopian Tube as a Promising Tool for Ovarian Cancer Early Detection
Published on: July 25, 2017
Ovarian cancer arising from the proximal fallopian tube in a patient with a BRCA2 mutation
Nora Badiner1, Corbyn M Nchako1, Lucy Ma2
1NY Presbyterian Weill Cornell Medical Center, Department of Obstetrics and Gynecology, 525 East 68 Street, Box 122, New York, NY 10065, USA.
Abstract:
Patients with BRCA mutations are at high risk of high grade serous ovarian cancer. A paradigm shift has resulted in the current understanding that many cases of ovarian cancer actually arise from the fimbriated fallopian tube. The case presented here involves fallopian tube carcinoma arising from the cornua of the uterus in a BRCA2 carrier. This case suggests that pathologic analysis of risk-reducing bilateral salpingo-oophorectomy (RRBSO) specimens via serial sectioning and extensively examining the fimbriated end (SEE-FIM) may be insufficient to diagnose all occult lesions of interest. This case also provides a new consideration in the ongoing debate over the role of concurrent hysterectomy at time of RRBSO in BRCA carriers.
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