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Updated: Nov 1, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

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Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling

D C Liu1, L L Song2, X Z Li1

  • 1Department of Urology, Xuzhou Central Hospital, No. 199 Jiefang South Road, Xuzhou, 221009, Jiangsu, People's Republic of China.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
|June 18, 2021
PubMed
Abstract

Insights

Circular RNA circHIPK3 promotes prostate cancer (PCa) progression and metastasis by regulating the miR-448/MTDH axis. This finding suggests circHIPK3 as a potential therapeutic target for PCa treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer (PCa) is a leading cancer diagnosis in men globally.
  • Circular RNAs (circRNAs) play a significant role in PCa's biological processes.
  • Understanding circRNA mechanisms is vital for PCa progression and metastasis research.

Purpose of the Study:

  • Investigate the molecular mechanism of circHIPK3 in prostate cancer.
  • Determine the role of circHIPK3 in PCa progression and metastasis.
  • Explore circHIPK3 as a potential therapeutic target for PCa.

Main Methods:

  • RNA interference and overexpression vectors were used to manipulate circHIPK3 and MTDH levels.
  • Luciferase reporter assays assessed interactions between circHIPK3, miR-448, and MTDH.
  • MTT, colony formation, and Transwell assays evaluated PCa cell proliferation and migration.

Main Results:

  • circHIPK3 levels were elevated in PCa tissues and cell lines.
  • Overexpression of circHIPK3 enhanced PCa cell migration, proliferation, and invasion.
  • circHIPK3 promoted MTDH expression by sponging miR-448, and enhanced tumor growth in vivo.

Conclusions:

  • circHIPK3 exhibits carcinogenic effects in PCa by modulating the miR-448/MTDH pathway.
  • circHIPK3 represents a potential therapeutic target for prostate cancer.
  • Further research into circHIPK3's role could lead to novel PCa treatments.
Keywords:
CircHIPK3MTDHMiR-448Prostate cancer

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