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Growth in children on kidney replacement therapy: a review of data from patient registries

Marjolein Bonthuis1, Jérôme Harambat2, Kitty J Jager3

  • 1ESPN/ERA-EDTA Registry, Department of Medical Informatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, J1B-108.1, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands. m.bonthuis@amsterdamumc.nl.

Pediatric Nephrology (Berlin, Germany)
|June 18, 2021
PubMed

Insights

Children with chronic kidney disease (CKD) on kidney replacement therapy (KRT) show improved final height due to better management. Early growth, especially by age two, is crucial for predicting final height in these children.

Area of Science:

  • Pediatric Nephrology
  • Growth and Development
  • Chronic Kidney Disease Management

Background:

  • Growth retardation is a significant complication for children with chronic kidney disease (CKD) requiring kidney replacement therapy (KRT).
  • Improved growth in childhood CKD correlates with better outcomes in morbidity and mortality.
  • Advances in conservative management, dialysis, immunosuppression, and transplantation have improved final height over time.

Purpose of the Study:

  • To analyze the relationship between early growth and final height in pediatric patients undergoing KRT.
  • To highlight the critical role of infancy and early childhood in determining final stature for children with CKD.

Main Methods:

  • Analysis of data from pediatric international registries, including the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-EDTA) Registry.
  • Examination of growth patterns and final height outcomes in children on KRT.

Main Results:

  • Preliminary data confirms a significant association between final height and height attained at 2 years of age in children on KRT.
  • Infancy represents a critical period for linear growth, impacting final adult height.

Conclusions:

  • Early growth assessment, particularly by age two, is vital for predicting final height in children with CKD on KRT.
  • Continued improvements in CKD management contribute to better growth outcomes and final height in pediatric patients.

Keywords:
ChildrenChronic kidney diseaseDialysisFinal heightGrowthKidney replacement therapyTransplant

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