Glandular cystic hyperplasia of the endometrium in the perimenopausal years

Fifty patients with simple glandular cystic hyperplasia of the endometrium-GCHE (one with partly adenomatous and two with partly atypical GCHE) were treated with Dabroston through 6 cycles. Daily dosage was 20-30 mg, higher dosage for those with exceeded optimal body weight. After 6 cycles of therapy curettage was repeated in 18 patients and histologic picture of the endometrium was analysed. The post-treatment curettage revealed GCHE in 5 patients, proliferative endometrium in 6 patients and secretory endometrium in 7 patients. In spite of GCHE neurovegetative perimenopausal symptoms were present in 62% before treatment and were even exaggerated in 34% of the patients during the treatment.