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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
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Takayasu arteritis: Prevalence and clinical presentation in Switzerland

Andrea D Gloor1, Laurève Chollet1, Lisa A Christ1

  • 1Department of Rheumatology, Immunology and Allergology, University Hospital (Inselspital) and, University of Bern, Bern, Switzerland.

Plos One
|June 18, 2021
PubMed
Abstract

Insights

Prevalence of Takayasu arteritis (TAK) in Switzerland is 14.5/million. Magnetic Resonance Angiography (MRA) detects subclinical disease activity, but EULAR criteria may miss cases with elevated ESR/CRP.

Area of Science:

  • Immunology
  • Rheumatology
  • Cardiology

Background:

  • Takayasu arteritis (TAK) is a rare immune-mediated vasculitis affecting the aorta and its branches.
  • Understanding the epidemiological characteristics and disease activity in TAK is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence and incidence of Takayasu arteritis (TAK) in Switzerland.
  • To evaluate disease activity using established criteria and assess the performance of Magnetic Resonance Angiography (MRA).

Main Methods:

  • Prevalence and incidence were calculated using national statistical data.
  • Disease activity was assessed using revised European League Against Rheumatism (EULAR) criteria.
  • MRA was utilized to visualize aortic stenosis and inflammation.

Main Results:

  • Calculated prevalence of 14.5/1,000,000 inhabitants and incidence of 0.3/1,000,000 per year.
  • MRA identified subclinical disease activity (aortic wall enhancement) in 10 patients in remission.
  • EULAR criteria missed 5 patients with disease activity indicated by isolated ESR/CRP elevation.

Conclusions:

  • MRA is valuable for detecting subclinical disease activity in Takayasu arteritis.
  • Current EULAR criteria may underestimate disease activity in patients with isolated inflammatory marker elevation.

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